abstract：:Interleukin-15 (IL-15) is a novel IL-2-like cytokine expressed by cells of the monocyte/macrophage and epithelial lineages. Cytokines might be involved in the pathogenesis of multiple sclerosis (MS). Using immunocytochemistry, we analysed spontaneous expression of IL-15 by peripheral blood (PB) and cerebrospinal fluid...

journal_title：Scandinavian journal of immunology

authors： Pashenkov M,Mustafa M,Kivisäkk P,Link H

更新日期：1999-09-01 00:00:00

abstract：:We have previously reported that a cytosolic alkaline fraction (FI) obtained from epimastigotes of Trypanosoma cruzi promotes the activation, proliferation and differentiation of normal murine B cells into antibody-secreting plasmocytes. Neither the mechanism nor the cells involved in the FI-induced polyclonal B-cell ...

journal_title：Scandinavian journal of immunology

authors： Montes CL,Zuñiga E,Minoprio P,Vottero-Cima E,Gruppi A

更新日期：1999-08-01 00:00:00

abstract：:The aim of this study was to evaluate nocturnal and diurnal urinary melatonin excretion in a group of ischaemic stroke patients, and to verify if a possible impairment of this excretion could be linked with some changes of immunological and neuro-psychic status. We assessed 13 ischaemic stroke patients and five health...

journal_title：Scandinavian journal of immunology

authors： Fiorina P,Lattuada G,Silvestrini C,Ponari O,Dall'Aglio P

更新日期：1999-08-01 00:00:00

abstract：:Inflammatory cytokines appear to be involved in damage to Schwann cells, myelin and axons, although the exact role of the different cytokines is uncertain. The direct injection model offers a new and simplified way of examining the mechanisms of early inflammation in the peripheral nervous system. The present study wa...

journal_title：Scandinavian journal of immunology

authors： Pelidou SH,Deretzi G,Zou LP,Quiding C,Zhu J

更新日期：1999-07-01 00:00:00

abstract：:The initial stage of Wegener's Granulomatosis (WG) is often marked by symptoms of infection and it has been postulated that a bacterial infection could be the aetiologic factor of this disease. The objective of our work was to investigate T-cell-mediated immunity in WG by testing proliferative responses on bacterial a...

journal_title：Scandinavian journal of immunology

authors： Mayet WJ,Märker-Hermann E,Schlaak J,Meyer Zum Büschenfelde KH

更新日期：1999-06-01 00:00:00

abstract：:Granulocyte colony-stimulating factor (G-CSF) possesses an antimicrobial effect in several animal models of infection. To evaluate a possible effect of G-CSF on the course of pneumococcal meningitis, rabbits infected intracisternally (i.c.) with Streptococcus pneumoniae type 3 (n = 7) received 50 microgram/kg of rhG-C...

journal_title：Scandinavian journal of immunology

authors： Schmidt H,Stuertz K,Brück W,Chen V,Stringaris AK,Fischer FR,Nau R

更新日期：1999-05-01 00:00:00

abstract：:The cytokine interleukin (IL)-10 has immune response down-regulatory properties, which include suppression of the synthesis of pro-inflammatory cytokines such as interferon (IFN)-gamma and of major histocompatibility complex (MHC) class II expression on monocytes. To further elucidate the involvement of IL-10 in multi...

journal_title：Scandinavian journal of immunology

authors： Ozenci V,Kouwenhoven M,Huang YM,Xiao B,Kivisäkk P,Fredrikson S,Link H

更新日期：1999-05-01 00:00:00

abstract：:The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated wit...

journal_title：Scandinavian journal of immunology

authors： Cardona PJ,Cooper A,Luquín M,Ariza A,Filipo F,Orme IM,Ausina V

更新日期：1999-04-01 00:00:00

abstract：:Pemphigus vulgaris is a cutaneous autoimmune disease in which the occurrence of autoantibodies directed against desmoglein-3 and other self-antigens has been well established in patient sera. However, V-region interactions (connectivity) of serum IgG and IgM have not been analysed to date. In this report, it has been ...

journal_title：Scandinavian journal of immunology

authors： Pacheco-García U,Tovar-Rivera T,Padierna-Olivos L,Rojas-Espinosa O,Sánchez-Colón S,Gutiérrez-Armenta M,Rivera-Benítez C,Masso-Rojas F,Sánchez-García FJ

更新日期：1999-04-01 00:00:00

abstract：:The aim of this study was to describe the kinetics of the cytokine release and the expression of activation markers on lymphocytes after stimulation of peripheral blood mononuclear cells (PBMC) with whole killed Streptococcus pneumoniae. The cytokine release and the expression of CD25 and HLA-DR on T cells, and CD69 o...

journal_title：Scandinavian journal of immunology

authors： Arvå E,Andersson B

更新日期：1999-03-01 00:00:00

abstract：:A synthetic peptide conjugate based on the N-terminal sequence of a 10 000 MW immunosuppressive serum protein (reOLT 4) was used to immunize female Lewis rats prior to mating, in order to determine whether blocking this protein had an effect on pregnancy. The N-terminal sequence of (reOLT 4) has close sequence homolog...

journal_title：Scandinavian journal of immunology

authors： Lord R,Goto S,Vari F,Long-Pan T,Chiang KC,Chen CL,Sunagawa M

更新日期：1999-02-01 00:00:00

abstract：:Sjögren's syndrome is characterized by dryness of the eyes and the mouth due to mononuclear cell infiltration of the lacrimal and salivary glands. The aetiology is unknown but autoimmunity is considered to play a significant role in the pathogenesis. Recent studies have focused on the fact that tear and salivary flow ...

journal_title：Scandinavian journal of immunology

authors： Humphreys-Beher MG,Brayer J,Yamachika S,Peck AB,Jonsson R

更新日期：1999-01-01 00:00:00

abstract：:Peripheral blood neutrophils from germ-free (GF), specific-pathogen-free (SPF) and conventional (CV) rats were compared. Besides neutropenia and impaired superoxide anion generation as previously reported, it was found that GF rats had lower phagocytic function (70%) and generated less nitric oxide than the other rats...

journal_title：Scandinavian journal of immunology

authors： Ohkubo T,Tsuda M,Suzuki S,El Borai N,Yamamura M

更新日期：1999-01-01 00:00:00

abstract：:To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irrad...

journal_title：Scandinavian journal of immunology

authors： Colucci F,Bergman ML,Lejon K,Holmberg D

更新日期：1998-12-01 00:00:00

abstract：:As part of an ongoing project aimed at the characterization of the MHC system in bony fishes, we have attempted to identify the class III region in the zebrafish (a teleost), a region that in higher vertebrates contains genes coding for complement proteins C2, Bf and C4. We obtained several genomic PAC clones by hybri...

journal_title：Scandinavian journal of immunology

authors： Gongora R,Figueroa F,Klein J

更新日期：1998-12-01 00:00:00

abstract：:The activation of complement and the release of TNF-alpha, IL-6 and IL-8 are important pathogenic factors behind organ dysfunction in sepsis. The aim of this study was to determine whether infusion of anti-TNF antibodies alters complement activation and plasma concentrations of pro-inflammatory cytokines at high doses...

journal_title：Scandinavian journal of immunology

authors： Bengtsson A,Redl H,Schlag G,Högåsen K,Götze O,Mollnes TE

更新日期：1998-11-01 00:00:00

abstract：:Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimenta...

journal_title：Scandinavian journal of immunology

authors： Zhu J,Deng GM,Diab A,Zwingenberger K,Bakhiet M,Link H

更新日期：1998-10-01 00:00:00

abstract：:Sera genetically deficient in either the alpha-gamma or the beta-subunit of complement component C8 virtually lack haemolytic activity. We have studied the formation and the structural organization of the soluble terminal complement complex (TCC) assembled in these sera following activation with cobra venom factor (CV...

journal_title：Scandinavian journal of immunology

authors： Høgåsen K,Mollnes TE,Nürnberger W,Pausa M,Fukumori Y,Tedesco F

更新日期：1998-09-01 00:00:00

abstract：:Prolonged antigenic stimulation results in lymphocyte shedding of CD27, a member of the tumour necrosis factor receptor (TNFR) family, and transformation to a stable phenotype capable of synthesizing interleukin-4 (IL-4). Co-expression of alpha4beta7 identifies those cells with gut-homing potential. We have investigat...

journal_title：Scandinavian journal of immunology

authors： Meenan J,Spaans J,Grool TA,Lammers K,Pals S,Tytgat GN,van Deventer SJ

更新日期：1998-09-01 00:00:00

abstract：:Coeliac disease probably results from a T-cell response to wheat gliadin and is associated to HLA-DQ2. No gliadin epitopes recognized by intestinal T cells have yet been identified, limiting our understanding of the pathogenesis. Gut-lesion-derived DQ2-restricted T cells from coeliac disease patients were used to iden...

journal_title：Scandinavian journal of immunology

authors： Sjöström H,Lundin KE,Molberg O,Körner R,McAdam SN,Anthonsen D,Quarsten H,Norén O,Roepstorff P,Thorsby E,Sollid LM

更新日期：1998-08-01 00:00:00

abstract：:Propagermanium is an organic germanium compound with immunopotentiating activity. We examined the hepatoprotective effect of propagermanium and its mechanism in an experimental animal model of acute liver injury induced with Corynebacterium parvum (C. parvum) and lipopolysaccharide (LPS) injection. Oral pretreatment w...

journal_title：Scandinavian journal of immunology

authors： Yokochi S,Ishiwata Y,Hashimoto H,Ninomiya F,Suzuki T

更新日期：1998-08-01 00:00:00

abstract：:The stem cells for the definitive haematopoiesis are derived from intra-embryonic sources originally described in an avian model and later also in mammals. However, the molecular make-up of the early embryonic haematopoietic progenitors is not yet clearly defined. We have recently characterized the phenotype of prethy...

journal_title：Scandinavian journal of immunology

authors： Lampisuo M,Katevuo K,Lassila O

更新日期：1998-07-01 00:00:00

abstract：:Direct contact between lymphokine-activated killer (LAK) cells and tumour cells is believed to be imperative for initiating tumour cell lysis in vitro as well as in vivo. In order to optimize adoptive immunotherapy (AIT) it is therefore desirable to identify the LAK cell subtype, which ensures maximal infiltration of ...

journal_title：Scandinavian journal of immunology

authors： Kjaergaard J,Hokland M,Nannmark U,Hokland P,Basse P

更新日期：1998-06-01 00:00:00

abstract：:Susceptibility to autologous and heterologous neutralization of primary human immunodeficiency virus (HIV)-1 isolates belonging to subtype B, to the B"-variant of subtype B or to subtype F from infected individuals residing in Rio de Janeiro was assayed. A lower infectivity of the B"- and F isolates when compared to t...

journal_title：Scandinavian journal of immunology

authors： Bongertz V,Costa CI,Guimarães ML,Grinsztejn B,João Filho EC,Galvão-Castro B,Morgado MG

更新日期：1998-06-01 00:00:00

abstract：:The effect of adjuvant on induction of human papillomavirus type 16 E7 protein-specific cytotoxic T lymphocytes (CTL) and immunoglobulin G (IgG)2a antibody was studied in C57BL/6 J mice immunized with various adjuvants and E7 protein. Quil-A adjuvant, but not complete Freund's adjuvant (CFA) or Algammulin, induced a T...

journal_title：Scandinavian journal of immunology

authors： Fernando GJ,Stewart TJ,Tindle RW,Frazer IH

更新日期：1998-05-01 00:00:00

abstract：:The c-Met oncoprotein is a cell-surface receptor for hepatocyte growth factor (HGF). Signals through HGF and c-Met have been appreciated for their crucial roles in the development of many cell types, including liver cells. The present study examined whether c-Met is expressed in the thymus and whether c-Met/HGF signal...

journal_title：Scandinavian journal of immunology

authors： Tamura S,Sugawara T,Tokoro Y,Taniguchi H,Fukao K,Nakauchi H,Takahama Y

更新日期：1998-04-01 00:00:00

abstract：:Factor B is an essential component of the complement cascade which forms the C3 and C5 convertase of the alternative pathway. Factor B cleavage products also function as cofactors in antibody-independent monocyte-mediated cytotoxicity, macrophage spreading, plasminogen activation and proliferation of B lymphocytes. Se...

journal_title：Scandinavian journal of immunology

authors： Pekna M,Hietala MA,Landin A,Nilsson AK,Lagerberg C,Betsholtz C,Pekny M

更新日期：1998-04-01 00:00:00

abstract：:During B-cell development in the avian bursa of Fabricius most of the developing B cells die by apoptosis and only a minority survive to emigrate into the periphery. Recently, it has been shown that when developing bursal cells become mature and ready to migrate they start to express chL12 antigen. The expression of t...

journal_title：Scandinavian journal of immunology

authors： Lampisuo M,Arstila TP,Liippo J,Lassila O

更新日期：1998-03-01 00:00:00

abstract：:The production of type 1 (interferon or IFN-gamma) and type 2 (interleukin or IL-4 and IL-10) cytokines by mitogen-stimulated peripheral blood mononuclear cells (PBMCs) obtained from asymptomatic human immunodeficiency virus-seropositive (HIV+) patients untreated with any antiviral, antibacterial or antimycotic drugs,...

journal_title：Scandinavian journal of immunology

authors： Canaris AD,Caruso A,Licenziati S,Cantalamessa A,De Francesco MA,Fallacara F,Fiorentini S,Dima F,Martinelli F,Manca N,Balsari A,Turano A

更新日期：1998-02-01 00:00:00

abstract：:Sera from patients with primary biliary cirrhosis recognize various cellular components, such as mitochondria, centromere, nuclear envelope, and multiple nuclear dot antigens. There also appears to be a novel antibody reacting with a particular protein in these sera. The presence of this antibody was investigated by d...

journal_title：Scandinavian journal of immunology

authors： Miyachi K,Matsushima H,Hankins RW,Hirakata M,Mimori T,Hosaka H,Amagasaki Y,Miyakawa H,Kako M,Shibata M,Onozuka Y,Ueno U

更新日期：1998-01-01 00:00:00

abstract：:We examined the progression of articular destruction and the production of tumour necrosis factor-alpha (TNF-alpha) in antigen-induced arthritis (AIA) in rabbits, i.e. flare-ups of inflammation induced by repeated intra-articular injections (single, twice and three times) of antigen. A marked progression of articular ...

journal_title：Scandinavian journal of immunology

authors： Idogawa H,Imamura A,Onda M,Umemura T,Ohashi M

更新日期：1997-12-01 00:00:00

abstract：:A Gross virus induced rat T cell lymphoma G1-Tc1 and a Moloney virus induced mouse T cell lymphoma YAC-1 are shown to exert a strong cytotoxic activity against rat yolk sac tumours but not to various types of rat, mouse or human normal cells or tumour cell lines including carcinomas, sarcomas, lymphomas and gliomas. B...

journal_title：Scandinavian journal of immunology

authors： Lindvall M,Eriksson H,Hedlund G,Sjögren HO

更新日期：1997-11-01 00:00:00

abstract：:Interferon gamma (IFN-gamma) production as a measure of cellular sensitization was studied by detection of the cytokine in culture supernatant by enzyme immunoassay (EIA) and by measuring cellular mRNA using the reverse transcriptase polymerase chain reaction (RT-PCR) method. These assays were compared to the standard...

journal_title：Scandinavian journal of immunology

authors： Halminen M,Klemetti P,Vaarala O,Hurme M,Ilonen J

更新日期：1997-10-01 00:00:00

abstract：:The interferon-alpha and -beta (IFN-alpha/beta) producing ability of the two murine dendritic cell (DC) lines D2SC/1 and FSDC was studied. The D2SC/1 cells produced IFN-alpha and -beta when stimulated by herpes simplex virus (HSV), Sendai virus (SV) or by the bacteria Escherichia coli or Staphylococcus aureus Cowan I....

journal_title：Scandinavian journal of immunology

authors： Eloranta ML,Sandberg K,Ricciardi-Castagnoli P,Lindahl M,Alm GV

更新日期：1997-09-01 00:00:00

abstract：:Intradermal inoculation of mice with naked plasmid DNA encoding the regulatory HIV-1 Nef protein was shown to induce Nef-specific T and B cell responses. Co-inoculation with an expression vector encoding murine granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine known to facilitate the induction of p...

journal_title：Scandinavian journal of immunology

authors： Svanholm C,Löwenadler B,Wigzell H

更新日期：1997-09-01 00:00:00

abstract：:The functional T-cell repertoire in the inflamed joint of a patient with rheumatoid arthritis was analysed at the clonal level. Using limiting dilution techniques and selecting for growth of in vivo activated and/or autoreactive T cells, 149 T-cell lines were established. They were tested in a proliferation assay for ...

journal_title：Scandinavian journal of immunology

authors： Melchers I,Jooss-Rüdiger J,Peter HH

更新日期：1997-08-01 00:00:00

abstract：:This study was designed to determine seasonal changes in cytokines, soluble CD23 and specific IgE in the serum of patients with seasonal allergic rhinitis, and the effect of immunotherapy on these seasonal changes. Fifty-four patients with seasonal allergic rhinitis caused by Japanese ceder pollens were divided into a...

journal_title：Scandinavian journal of immunology

authors： Ohashi Y,Nakai Y,Kakinoki Y,Ohno Y,Tanaka A,Masamoto T,Sakamoto H,Washio Y,Kato A

更新日期：1997-07-01 00:00:00

abstract：:Entamoeba histolytica can cause invasive disease by disruption of the intestinal barriers and subsequent lysis of the intestinal cells. Adherence to and contact dependent killing of host cells requires the galactose inhibitable lectin. To elucidate the mechanism whereby E. histolytica influences host defence, the auth...

journal_title：Scandinavian journal of immunology

authors： Kim JM,Jung HC,Jin DZ,Im KI,Song IS,Kim CY

更新日期：1997-06-01 00:00:00

abstract：:Psoriasis is a T-cell mediated inflammatory skin disease which has been associated with group A, beta-haemolytic streptococcal infections. Four 20 a.a. long M6-peptides sharing 5-6 a.a. sequences with human epidermal keratins were identified. To investigate the role of potentially cross-reactive T cells in the pathoge...

journal_title：Scandinavian journal of immunology

authors： Sigmundsdottir H,Sigurgeirsson B,Troye-Blomberg M,Good MF,Valdimarsson H,Jonsdottir I

更新日期：1997-06-01 00:00:00

abstract：:The survival of T cells derived from the early waves of thymus colonization by haemopoietic cell precursors was investigated by grafting thymus from B6.Thy1.1 day 14 embryos (E14) (first wave) or E17 or newborn thymus (subsequent waves) into allogeneic athymic BALB/c (Thy1.2) nude recipients. The survival of donor-der...

journal_title：Scandinavian journal of immunology

authors： Thomas-Vaslin V,Salaün J,Coltey M,Vaigot P,Fucs R

更新日期：1997-05-01 00:00:00